Retatrutide Peptide

Description

Retatrutide peptide from Prime Peptides is a GIP, GLP-1 and glucagon receptor agonist, supplied as freeze-dried powder in 10mg, 30mg and 60mg vials. Choose the strength you need from the Size menu. Prime Peptides supplies it for in-vitro research only.

What is Retatrutide?

Retatrutide (LY3437943) is a single 39-amino-acid peptide from Eli Lilly that acts on three receptors at once: GIP, GLP-1 and glucagon. That makes it the first triple hormone receptor agonist to reach late-stage trials.

A fatty acid side chain lets it bind albumin in the blood, which stretches its half-life to about six days and makes once-weekly study possible. It isn’t approved anywhere yet.

How Retatrutide works

Retatrutide hits three receptors with one peptide: GIP, GLP-1 and glucagon. The first two are incretins that boost glucose-dependent insulin release and, in GLP-1’s case, curb appetite and slow stomach emptying.

The glucagon part is the unusual bit. Glucagon raises energy expenditure and pushes the liver to burn fat, so pairing it with the incretins is meant to work on both sides of energy balance. That’s the main reason researchers compare it with the dual and single agonists.

Retatrutide peptide specifications

• Compound: Retatrutide
• Also known as: LY3437943
• CAS number: 2381089-83-2
• Molecular weight: 4,731.3 g/mol
• Structure: 39 amino acids with a fatty diacid side chain
• Sizes: 10mg, 30mg, 60mg
• Form: lyophilized (freeze-dried) powder
• Label: Prime, For Research Only, Lyophilized Powder
• SKU: PRIME-RETA
• Intended use: laboratory research only

Published studies on Retatrutide

Jastreboff and colleagues reported the phase 2 obesity trial in the New England Journal of Medicine in 2023. At the highest dose, average weight loss reached 24.2% at 48 weeks, the largest figure any incretin compound had shown at that stage.

A substudy in Nature Medicine (Sanyal and colleagues, 2024) found large drops in liver fat, and a separate phase 2 trial in type 2 diabetes was published in The Lancet in 2023. Lilly’s phase 3 TRIUMPH program is testing it in obesity, diabetes, knee osteoarthritis and sleep apnea.

The original papers are free to search through this PubMed search for Retatrutide, run by the U.S. National Library of Medicine.

Retatrutide compared with similar compounds

Retatrutide activates three receptors at once: GIP, GLP-1 and glucagon. Here’s how the nearest options in our range differ:

• Tirzepatide activates two incretin receptors, GIP and GLP-1
• Semaglutide activates the GLP-1 receptor only and lasts about a week, which makes it the most studied compound in the group
• Eloralintide is a newer long-acting amylin receptor agonist from Lilly, studied for appetite and gastric emptying
• AOD-9604 is a modified 176-191 fragment of growth hormone, studied for fat breakdown without GH’s growth effects
• MOTS-c is a short peptide coded in mitochondrial DNA and linked to AMPK

Each one approaches metabolism from a different side: gut hormone receptors, amylin, a growth hormone fragment or the mitochondria. Compare them in our weight loss peptides.

Retatrutide peptide mixing guide

Start from the 10mg in the vial and pick a volume. These are the concentrations you get:

• 1mL of diluent gives 10mg per mL
• 2mL of diluent gives 5mg per mL
• 3mL of diluent gives 3.333mg per mL

Let the vial reach room temperature, swab the stopper with alcohol and let the diluent run slowly down the inside of the glass. Swirl gently until the solution is clear. Shaking creates foam and can damage the peptide. Prime stocks bacteriostatic water for exactly this step.

Keeping Retatrutide peptide fresh

Unopened Retatrutide peptide keeps best at -20°C. A fridge is fine if you’ll use it soon. After reconstitution it belongs at 2 to 8°C, and most protocols use it up within 28 days.

Keep mixed vials upright so the liquid doesn’t sit against the stopper.

Checking the quality of Retatrutide peptide

On the Prime vial you’ll see the compound name, the words “Lyophilized Powder” and a research-only notice. File the order confirmation with your notes so each vial can be traced to its delivery.

Independent verification usually means HPLC for purity plus mass spectrometry for identity. One without the other only tells half the story.

Write the order number and the date opened on every vial. If a result looks unusual later, you can trace it back to one delivery.

Retatrutide peptide sizes and pricing

Every Retatrutide size we sell is on this page. Choose one from the Size menu next to the cart button:

• Retatrutide 10mg: $110.00 ($11.00 per mg)
• Retatrutide 30mg: $230.00 ($7.67 per mg)
• Retatrutide 60mg: $325.00 ($5.42 per mg)

The smallest vial is the cheapest way to test a method. Once the protocol is fixed, the larger vials cost less per milligram and mean fewer reconstitutions.

Related to Retatrutide peptide

• Tirzepatide Peptide, a GIP/GLP-1 agonist
• Eloralintide 10mg, an amylin agonist
• Semaglutide Peptide, a GLP-1 agonist
• MOTS-c 10mg, a mitochondrial peptide
• AOD-9604 5mg, an hGH fragment

Browse the complete list in our weight loss peptides, or head back to the Prime Peptides home page to see every category.

Retatrutide peptide FAQ

How much is in each Retatrutide peptide vial?

10mg, 30mg and 60mg, depending on the size you choose.

Is there a discount on Retatrutide peptide?

Yes. Pay with crypto at checkout and you get 15% off your order.

What do I mix Retatrutide peptide with?

Most labs use our bacteriostatic water. The mixing guide on this page lists the strength you get from each volume.

How should Retatrutide peptide be stored?

Freeze the sealed vial at -20°C. After mixing, move it to the fridge at 2 to 8°C and finish it inside roughly 28 days.

Can Retatrutide be used in people or animals?

No. Prime Peptides sells it for laboratory research only. It isn’t approved for human or veterinary use.

Get Retatrutide peptide from Prime Peptides

Ready to order? Retatrutide peptide costs from $110.00, it’s in stock and shipping is free, and you only need to choose a size first. Paying in crypto takes 15% off.

Compounds that fit the same study sit in our weight loss peptides.

Prime Peptides sells this product for in-vitro and laboratory research only. It isn’t a medicine, food or dietary supplement, and it can’t be given to people or animals. The FDA has not evaluated any statement on this page. Buyers must be 21 or older and qualified to handle research chemicals.